Optimization of Preparation Process and Pharmacokinetics of APAP Double-Release Pellet Capsules

In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, immediate and sustained release pellets certain proportion were by fluidized bed coating extrusion spheroidization process, respectively. It founded that both immediate-release sustained-release had smooth round surfaces. The particle size distribution ranged evenly from 16 35 mesh. Response surface plots showed optimal preparation prescription for ethanol concentration (X 1 ) 70%, 20%, MCC 2 40%, PVP K30 3 sucrose core 20%; HPMC (X* 6.5%, 30%, EC 4%, lactose 6%. results pharmacokinetic analysis revealed that, after orally administered, compared conventional tablets, plasma levels in blood circulation dramatically rose significant peaks as result quick slow significantly prolonged effective time drugs blood. Finally, antipyretic-analgesic effects obtained.